HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1199588Generated: November 1, 2026
Hydrochloric Acid → cis 4-Thiocyanatomethyl-3-amino-2-oxo-azetidine hydrochloride
https://huagongshe.com/reaction/1199588
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | cis 4-Thiocyanatomethyl-3-phthalimido-2-oxo-azetidine | HCID 86743759 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | cis 4-Thiocyanatomethyl-3-amino-2-oxo-azetidine hydrochloride | HCID 86743760 | — |
Reaction Steps
A hot mixture of 1.45 g of the product of Step B in 15 ml of hot dioxane was cooled and 0.3 ml of hydrazine hydrate was added thereto. The mixture was stirred for 50 minutes at 20° C. and 7.5 ml of N hydrochloric acid were added thereto. The mixture was stirred for 15 hours and vacuum filtered. The filtrate was rinsed with water and the filtrate was evaporated to dryness to obtain 0.914 g of cis 4-thiocyanatomethyl-3-amino-2-oxo-azetidine hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04900728 |
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| Source dataset | uspto-grants-1990_02 |
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| ORD ID | ord-6af5fcba448a4060a8af398bef1a3685 |
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| Source note | uspto-grants-1990_02 |
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