Benzoic acid, 2-(isocyanatosulfonyl)-, methyl ester → HCID 20070846, compound

Participants

Reaction Conditions

Reaction Steps

7.0 g of 2-amino-4-methoxy-6-(4,5-dihydrothiazol-2-yl)pyrimidine are suspended in 50 ml of abs. acetonitrile, and 6.6 g of 2-methoxycarbonylphenylsulfonylisocyanate are added. There is formed a clear solution with heating, and the product subsequently precipitates in crystalline form. After the reaction mixture has been stirred for 3 hours at 20°-25° C., it is cooled to 0° C. and the solid substance is separated. There is thus obtained N-(2-methoxycarbonylphenyl-sulfonyl)-N'-[4-methoxy-6-(4,5-dihydrothiazol-2-yl)-thiomethyl-pyrimidin-2-yl]-urea, m.p. 135°-145° C. (decomp.).

Provenance & Evidence