HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane → N-(2-methoxycarbonylphenyl-sulfonyl)-N'-[4-methoxy-6-(pyridin-2-ylthiomethyl)-pyrimidin-2-yl]-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Benzoic acid, 2-(isocyanatosulfonyl)-, methyl ester | HCID 156281 | — |
| Reactant | 2-Amino-4-methoxy-6-(pyridin-2-ylthiomethyl)pyrimidine | HCID 20070842 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-(2-methoxycarbonylphenyl-sulfonyl)-N'-[4-methoxy-6-(pyridin-2-ylthiomethyl)-pyrimidin-2-yl]-urea | HCID 54268146 | — |
Reaction Steps
7.0 g of 2-amino-4-methoxy-6-(pyridin-2-ylthiomethyl)-pyrimidine and 6.8 g of 2-methoxycarbonylphenylsulfonylisocyanate are stirred in 50 ml of abs. acetonitrile for 2 hours at 20°-25° C. The turbid solution is filtered, and the solvent evaporated off in vacuo. The residue is crystallised from dioxane to thus obtain 5.5 g (37% of theory) of N-(2-methoxycarbonylphenyl-sulfonyl)-N'-[4-methoxy-6-(pyridin-2-ylthiomethyl)-pyrimidin-2-yl]-urea, which crystallises with 0.5 mol of dioxane, m.p. 175°-181° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04902336 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-ee34888e30f94ff1b8f8a50a12343c79 |
| Source note | uspto-grants-1990_02 |