HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)-6-methoxypyrimidin-2-amine → 2-Amino-4-methoxy-6-dimethylthiocarbamoylthiomethyl-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)-6-methoxypyrimidin-2-amine | HCID 13884815 | — |
| Reactant | Sodium dimethyldithiocarbamate dihydrate | HCID 23693613 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Amino-4-methoxy-6-dimethylthiocarbamoylthiomethyl-pyrimidine | HCID 20070829 | — |
Reaction Steps
18.5 g of dimethyldithiocarbamic acid sodium salt dihydrate and 17.4 g of 2-amino-4-chloromethyl-6-methoxypyrimidine are refluxed in 100 ml of ethanol for 30 minutes. After the mixture has been cooled, it is diluted with about 1 litre of water, and the product which has precipitated is separated and dried. The yield is 23.0 g (89% of theory) of 2-amino-4-methoxy-6-dimethylthiocarbamoylthiomethyl-pyrimidine, m.p. 118°-120° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04902336 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-203af61f348142aba58aff9cb254be18 |
| Source note | uspto-grants-1990_02 |