1-Chloro-4-(methylsulfonyl)benzene → 2-Chloro-5-(methylsulfonyl)benzenesulfonyl chloride

Participants

Reaction Conditions

Reaction Steps

To 300 ml (4.53 mol) of chlorosulfonic acid was added 300 g (1.57 mol) of 4-methanesulfonylchlorobenzene at room temperature while stirring. The mixture was heated to 120° C., at which stirring was continued for 16 hours. After cooling, the reaction mixture was poured into ice-water, and the resulting crystals were collected by filtration and air-dried to obtain 293 g (yield: 64%) of HD-39a.

Provenance & Evidence