HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazinamide → HCID 14877963, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazinamide | HCID 1046 | — |
| Reactant | Acetic acid ethanol | HCID 18476134 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Platinum oxide (PtO) | HCID 82844 | — |
| Product | HCID 14877963 | HCID 14877963 | — |
Reaction Steps
One hundred twenty-five grams of pyrazinamide were hydrogenated in the presence of 2.5 L of 6:1 ethanol/acetic acid and 62.6 g of platinum oxide at 60 psi and 60° C. After hydrogen uptake ceased, the reaction mixture was filtered through a Celite® pad and concentrated in vacuo. Trituration with ethyl acetate afforded 219.57 g of the desired subtitle intermediate, m.p. 90-92° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04902687 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-96252fbb7b3f4a12ba5e77722c9778a7 |
| Source note | uspto-grants-1990_02 |