HCID 14989638, compound → HCID 14989641, compound

HRID 1199681Notes

Reaction equation

HRID 1199681 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[N:8][CH:9]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[N:8][CH:9]=1

Participants

4

Reactant 1

HCID 14989638HCID 14989638, compound

Product 1

HCID 14989641HCID 14989641, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 5-(5-nitropyrid-2-yl)pentanoic acid (6.0 g) in ethanol (140 ml) containing 10% palladium on carbon (0.6 g) was shaken under an atmosphere of hydrogen at 3.4 atmospheres pressure for 1 hour. The catalyst was removed by filtration, the filtrate was evaporated to dryness and the residue was recrystallised from acetonitrile to give the title compound as a cream coloured solid (4.04 g). m.p. 80°-82° C.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated to dryness
  3. customthe residue was recrystallised from acetonitrile

Sources & evidence

ORD record
ord-cf58030130874539b5a0b058f65ce707
Source dataset
uspto-grants-1990_02
Patent number
US04902698

Reaction notes

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