HCID 14989639, compound → 5-amino-2-Pyridinepropanoic acid

HRID 1199684Notes

Reaction equation

HRID 1199684 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[N:8][CH:9]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[N:8][CH:9]=1

Participants

4

Reactant 1

HCID 14989639HCID 14989639, compound

Product 1

HCID 149896425-amino-2-Pyridinepropanoic acidYield 90%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 3-(5-nitropyrid-2-yl)propionic acid (4.50 g) in ethanol (140 ml) containing 10% palladium on carbon (0.45 g) was shaken under an atmosphere of hydrogen at 3.4 atmospheres pressure for 1.5 hours. The catalyst was removed by filtration and the filtrate was evaporated to dryness. The residue was recrystallised from acetonitrile to give the title compound (3.43 g) m.p. 118°-120° C.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated to dryness
  3. customThe residue was recrystallised from acetonitrile

Sources & evidence

ORD record
ord-74ca1669f53f4947a3f1e81b6b1cd7ba
Source dataset
uspto-grants-1990_02
Patent number
US04902698

Reaction notes

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