Hydrochloric Acid → HCID 14989659, compound

Participants

Reaction Conditions

Reaction Steps

Sodium nitrite (6.08 g) in water (12 ml) was added over 20 minutes to a solution of methyl 4-(5-aminopyrid-2-yl)butanoate (7.48 g, 0.04 mole) in glacial acetic acid (20 ml) and concentrated hydrochloric acid (32 ml) stirred at -10° C. The solution was stirred for 15 minutes then added over 15 minutes to a solution of cuprous chloride (2 g) in glacial acetic acid saturated with sulphur dioxide at 10° C. The resulting solution was stirred at room temperature for 1 hour then poured into ice water (250 ml) and extracted with chloroform (3×200 ml). The chloroform extracts were dried over magnesium sulphate and the solvent was removed to give the title compound as a pale green oil which was used without further purification.

Provenance & Evidence