反应详情

A solution of 4-methoxybenzenesulphonyl chloride (2.06 g) and 4-(5-aminopyrid-2-yl)butanoic acid (1.8 g) in pyridine (15 ml) was allowed to stand at room temperature for 18 hours. The solvent was removed and the residue was dissolved in water and treated with dilute hydrochloric acid to give a solution at pH 4.5. The resulting precipitate was collected and recrystallised from ethanol to give the title compound (1.96 g) as prisms. m.p. 129°-130° C.

1. customThe solvent was removed
2. dissolutionthe residue was dissolved in water
3. additiontreated with dilute hydrochloric acid
4. customto give a solution at pH 4.5
5. customThe resulting precipitate was collected
6. customrecrystallised from ethanol