2-Methoxyacetohydrazide → HCID 19865760, compound

HRID 1199773Notes

Reaction equation

HRID 1199773 reaction equation
[F:1][C:2]1[C:7]2[C:8]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Br:20])=[N:9][CH2:10][C:11](=S)[NH:12][C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH3:21][O:22][CH2:23][C:24]([NH:26][NH2:27])=O>C(O)CCC>[F:1][C:2]1[C:7]2[C:8]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Br:20])=[N:9][CH2:10][C:11]3[N:12]([C:24]([CH2:23][O:22][CH3:21])=[N:26][N:27]=3)[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 27595322-MethoxyacetohydrazideHCID 19865845HCID 19865845, compound

Product 1

HCID 19865760HCID 19865760, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

In the manner given in Example 1, a solution of 1,3-dihydro-6-fluoro-5-(o-bromophenyl)-2H-1,4-benzodiazepine-2-thione in n-butyl alcohol was heated to reflux with methoxyacetic acid hydrazide to give 7-fluoro-1-(methoxymethyl)-6-(o-bromophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-842177fb8617467b9a3045c04a2e46d8
Source dataset
uspto-grants-1990_02
Patent number
US04902794

Reaction notes

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