2-Methoxyacetohydrazide → HCID 19865753, compound

HRID 1199777Notes

Reaction equation

HRID 1199777 reaction equation
[CH3:1][C:2]1[CH:22]=[CH:21][C:5]2[C:6]([C:12]3[CH:17]=[CH:16][C:15]([CH:18]([CH3:20])[CH3:19])=[CH:14][CH:13]=3)=[N:7][CH2:8][C:9](=S)[NH:10][C:4]=2[CH:3]=1.[CH3:23][O:24][CH2:25][C:26]([NH:28][NH2:29])=O>C(O)CCC>[CH3:1][C:2]1[CH:22]=[CH:21][C:5]2[C:6]([C:12]3[CH:17]=[CH:16][C:15]([CH:18]([CH3:20])[CH3:19])=[CH:14][CH:13]=3)=[N:7][CH2:8][C:9]3[N:10]([C:26]([CH2:25][O:24][CH3:23])=[N:28][N:29]=3)[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 27595322-MethoxyacetohydrazideHCID 19865848HCID 19865848, compound

Product 1

HCID 19865753HCID 19865753, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

In the manner given in Example 1, a solution of 1,3-dihydro-8-methyl-5-(p-isopropylphenyl)-2H-1,4-benzodiazepine-2-thione in n-butyl alcohol was heated to reflux with methoxyacetic acid hydrazide to give 9-methyl-1-(methoxymethyl)-6-(p-isopropylphenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-3656dbd4a1a644ed81ad1828335dab5e
Source dataset
uspto-grants-1990_02
Patent number
US04902794

Reaction notes

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