HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Hydroxyacetohydrazide → alpha-Hydroxyalprazolam
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Hydroxyacetohydrazide | HCID 350536 | — |
| Reactant | Thionordiazepam | HCID 826706 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | alpha-Hydroxyalprazolam | HCID 162244 | — |
Reaction Steps
In the manner given in Example 11, a solution of 1,3-dihydro-7chloro-5phenyl-2H-1,4-benzodiazepine-2-thione in n-butyl alcohol was heated to reflux with hydroxyacetic acid hydrazide to give 8-chloro-1-(hydroxymethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine of melting point 204°-206.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04902794 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-247d53bbcf4c4920a81cefd83e3aa5e1 |
| Source note | uspto-grants-1990_02 |