2-Hydroxyacetohydrazide → HCID 19865786, compound

HRID 1199781Notes

Reaction equation

HRID 1199781 reaction equation
[N+:1]([C:4]1[CH:22]=[CH:21][C:7]2[C:8]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[F:20])=[N:9][CH2:10][C:11](=S)[NH:12][C:6]=2[CH:5]=1)([O-:3])=[O:2].[OH:23][CH2:24][C:25]([NH:27][NH2:28])=O>C(O)CCC>[N+:1]([C:4]1[CH:22]=[CH:21][C:7]2[C:8]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[F:20])=[N:9][CH2:10][C:11]3[N:12]([C:25]([CH2:24][OH:23])=[N:27][N:28]=3)[C:6]=2[CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 3505362-HydroxyacetohydrazideHCID 19865782HCID 19865782, compound

Product 1

HCID 19865786HCID 19865786, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

In the manner given in Example 11, a solution of 1,3-dihydro-8-nitro-5-(o-fluorophenyl)-2H-1,4-benzodiazepine-2-thione in n-butyl alcohol is heated to reflux with hydroxyacetic acid hydrazide to give 9-nitro-1-(hydroxymethyl)-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-99db5d3fb4444ffdba6f18d824c16e5b
Source dataset
uspto-grants-1990_02
Patent number
US04902794

Reaction notes

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