2-Hydroxyacetohydrazide → HCID 19865829, compound

HRID 1199785Notes

Reaction equation

[CH2:1]([S:4][C:5]1[C:15]2[NH:14][C:13](=S)[CH:12]([CH3:17])[N:11]=[C:10]([C:18]3[C:23]([CH2:24][CH3:25])=[CH:22][CH:21]=[CH:20][C:19]=3[CH2:26][CH3:27])[C:9]=2[CH:8]=[CH:7][CH:6]=1)[CH2:2][CH3:3].[OH:28][CH2:29][C:30]([NH:32][NH2:33])=O>>[CH2:1]([S:4][C:5]1[C:15]2[N:14]3[C:30]([CH2:29][OH:28])=[N:32][N:33]=[C:13]3[CH:12]([CH3:17])[N:11]=[C:10]([C:18]3[C:19]([CH2:26][CH3:27])=[CH:20][CH:21]=[CH:22][C:23]=3[CH2:24][CH3:25])[C:9]=2[CH:8]=[CH:7][CH:6]=1)[CH2:2][CH3:3]

Participants

Reactant 2

HCID 3505362-Hydroxyacetohydrazide

HCID 19865841HCID 19865841, compound

Product 1

HCID 19865829HCID 19865829, compound

Procedure

In the manner given in Example 11, a solution of 1,3-dihydro-9-propylthio-3-methyl-5-(2,6-diethylphenyl)-2H-1,4-benzodiazepine-2-thione and hydroxyacetic acid hydrazide in n-butylalchol was refluxed to give 10-propylthio-1-(hydroxymethyl)-4-methyl-6-(2,6-diethylphenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record: ord-ed76fcba8bbd40dea1f9a32ed2319afe
Source dataset: uspto-grants-1990_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04902794

Reaction notes

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