2-Hydroxyacetohydrazide → HCID 19865759, compound

HRID 1199786Notes

Reaction equation

HRID 1199786 reaction equation
[CH3:1][S:2]([C:5]1[C:10]2[C:11]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=3)=[N:12][CH2:13][C:14](=S)[NH:15][C:9]=2[CH:8]=[C:7]([Br:24])[CH:6]=1)(=[O:4])=[O:3].[OH:25][CH2:26][C:27]([NH:29][NH2:30])=O>C(O)CCC>[CH3:1][S:2]([C:5]1[C:10]2[C:11]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=3)=[N:12][CH2:13][C:14]3[N:15]([C:27]([CH2:26][OH:25])=[N:29][N:30]=3)[C:9]=2[CH:8]=[C:7]([Br:24])[CH:6]=1)(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 3505362-HydroxyacetohydrazideHCID 19865824HCID 19865824, compound

Product 1

HCID 19865759HCID 19865759, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

In the manner given in Example 11, a solution of 1,3-dihydro-6-(methylsulfonyl)-8-bromo-5-(m-fluorophenyl)-2H-1,4-benzodiazepine-2-thione and hydroxyacetic acid hydrazide in n-butyl alcohol was refluxed to give 7-(methylsulfonyl)-9-bromo-1-(hydroxymethyl)-6-(m-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-bf967e35ee1c43fd98c19d99e00bceb3
Source dataset
uspto-grants-1990_02
Patent number
US04902794

Reaction notes

Loading…