phenylacetic anhydride → HCID 70359573, compound

HRID 1199791Notes

Reaction equation

HRID 1199791 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:14]([CH2:17][OH:18])=[N:15][N:16]=[C:12]3[CH2:11][N:10]=[C:9]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[Cl:25])[C:8]=2[CH:26]=1)([O-:3])=[O:2].[C:27]1([CH2:33][C:34]([O:36]C(=O)CC2C=CC=CC=2)=[O:35])[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>O>[C:27]1([CH2:33][C:34]([OH:36])=[O:35])[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:14]([CH2:17][OH:18])=[N:15][N:16]=[C:12]3[CH2:11][N:10]=[C:9]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[Cl:25])[C:8]=2[CH:26]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 316205phenylacetic anhydrideHCID 19865756(6-(2-Chlorophenyl)-8-nitro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-yl)methanol

Product 1

HCID 70359573HCID 70359573, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a manner similar to Example 12, a mixture of 8-nitro-1-(hydroxymethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine and phenylacetic anhydride was heated on the water bath to give 8-nitro-1-(hydroxymethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine phenylacetate (ester).

Sources & evidence

ORD record
ord-8f99d1cd18e54ead810e57e85af79a92
Source dataset
uspto-grants-1990_02
Patent number
US04902794

Reaction notes

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