反应详情

A 1.5 g portion of the compound of Example 2 was suspended in 30 ml of methanol, and hydrogen chloride gas was bubbled through the suspension for 1 minute. Then 30 ml of methanol was added over a 5 minute period while the addition of gas was continued. Then the mixture was heated under reflux for 2 hours, and was cooled and filtered. The solids were collected and dried to obtain 1.15 g of the desired product, m.p. 220°-222°.

1. customhydrogen chloride gas was bubbled through the suspension for 1 minute
2. additionThen 30 ml of methanol was added over a 5 minute period while the addition of gas
3. temperatureThen the mixture was heated
4. temperatureunder reflux for 2 hours
5. temperaturewas cooled
6. filtrationfiltered
7. customThe solids were collected
8. customdried