HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2-(beta,gamma-Dihydroxypropyl)amino-4,5-methylenedioxy-1-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Amino-1,2-propanediol | HCID 73561 | — |
| Reactant | 5,6-Dinitro-1,3-benzodioxole | HCID 611325 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(beta,gamma-Dihydroxypropyl)amino-4,5-methylenedioxy-1-nitrobenzene | HCID 13742674 | — |
Reaction Steps
0.6 mol (56.3g) of 3-amino-1,2-propanediol is added dropwise to a mixture, brought to reflux, prepared by adding 0.3 mol (63.6 g) of 4,5-methylenedioxy-1,2-dinitrobenzene and 46 ml of triethylamine to 90 ml of 96° strength ethanol. The reaction mixture is heated for 3 hours under reflux. After dilution with 600 ml of icecold water and neutralization with acetic acid, the expected product is drained. After recrystallization from acetonitrile, it melts at 120°-121° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04904276 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-017569fe652c4fc98ab7e26dce2c2ae6 |
| Source note | uspto-grants-1990_02 |