Ammonium Chloride → HCID 19864209, compound

HRID 1199908Notes

Reaction equation

HRID 1199908 reaction equation
[C:1]([C:5]1[O:6][C:7]2[CH:13]=[C:12]([N+:14]([O-])=[O:15])[C:11]([Cl:17])=[CH:10][C:8]=2[N:9]=1)([CH3:4])([CH3:3])[CH3:2].[Cl-].[NH4+]>C(O)C.O.[Zn]>[C:1]([C:5]1[O:6][C:7]2[CH:13]=[C:12]([NH:14][OH:15])[C:11]([Cl:17])=[CH:10][C:8]=2[N:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

6

Reactant 2

HCID 25517Ammonium ChlorideHCID 7612202-TERT-BUTYL-5-CHLORO-6-NITROBENZOXAZOLE

Product 1

HCID 19864209HCID 19864209, compoundYield 80.9%

Reagents, catalysts & solvents 3

HCID 23994ZincCatalystHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

200 g of 2-tert-butyl-5-chloro-6-nitrobenzoxazole was dispersed in a mixture of 600 ml of ethanol and 300 ml of water and to the mixture was added 42 g of ammonium chloride and then was gradually added zinc powder. The temperature rose to 70° C. due to generation of heat. The mixture was stirred for one hour and then, the inorganic substances were removed by filtration. To the filtrate was added 1.8 liters of water, and the crystals thusdeposited were collected by filtration. The crystals were dried to obtain 153 g of the desired compound.

Workup

  1. customrose to 70° C. due to generation
  2. temperatureof heat
  3. customthe inorganic substances were removed by filtration
  4. additionTo the filtrate was added 1.8 liters of water
  5. filtrationthe crystals thusdeposited were collected by filtration
  6. customThe crystals were dried

Sources & evidence

ORD record
ord-1b2b084b8f8d44148b5503e8e509b7ed
Source dataset
uspto-grants-1990_02
Patent number
US04904575

Reaction notes

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