Bromine → HCID 19864298, compound

Participants

Reaction Steps

A solution of bromine in acetic acid (1.03 ml, 10% v/v solution) was added dropwise to a stirred solution of 8-phenyl-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepine (0.53 g, 2 mmol, hydrochloride salt converted to free base by extraction between dichloromethane and aqueous ammonia) in acetic acid (5 ml) at room temperature. After 30 minutes the mixture was evaporated and the blue coloured solid residue recrystallised from ethanol (10 ml) to give 2-bromo-8-phenyl-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepine hydrobromide (m.p. 197°).

Provenance & Evidence