Acetic Acid → HCID 19864295, compound

Participants

Reaction Steps

A suspension of 6-methyl-2-nitro-8-phenyl-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepine hydrochloride (0.20 g) and 10% palladium on carbon (20 mg) in acetic acid (18 ml), acetic anhydride (2 ml) was hydrogenated on a Parr apparatus for 24 hours at 70 psi. The mixture was filtered and the filtrate evaporated. The residue was dissolved in water (30 ml), basified to pH~11 with ammonia solution and extracted with dichloromethane (2×50 ml). The extracts were dried filtered and evaporated to a yellow viscous oil. Crystallisation from toluene gave the title product (m.p. 180°).

Provenance & Evidence