HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → HCID 14677477, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 5-Aminoimidazole-4-carboxamide hydrochloride | HCID 66146 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 3-(Dimethylamino)-1-(4-methoxyphenyl)prop-2-en-1-one | HCID 722402 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 14677477 | HCID 14677477 | 40.2% |
Reaction Steps
A stirred mixture of 15.0 g of 3-dimethylamino-4'-methoxyacrylophenone (prepared as described in Example 8) and 9.2 g of 4-amino-5-imidazolecarboxamide hydrochloride in 450 ml of glacial acetic acid was heated at reflux for 24 hours. Evaporation of the solvent in vacuo gave a solid which was treated with saturated sodium bicarbonate solution, then washed with water and filtered to give colorless crystals. This material was treated with hot acetonitrile and collected by filtration. Recrystallization from ethanol gave 6.1 g of the desired product as yellow crystals, mp 246°-249° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04904658 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-c21cfe32d8c9452794321249b8715fa2 |
| Source note | uspto-grants-1990_02 |