Methyl iodide → HCID 19864371, compound

Participants

Reaction Steps

To a stirred suspension of 2.0 g of 4-[3-(trifluoromethyl)phenyl]-6H,8H-pyrimido[1,2,3-cd]purine-8,10-(9H)-dione (Example 41) in 20 ml of dry N,N-dimethylformamide was added 310 mg of sodium hydride (60% dispersion in mineral oil). The mixture was stirred at room temperature for 3 hours. To this mixture was added 2.0 ml of methyl iodide with continued stirring for 20 hours. The mixture was concentrated and the residue was treated with water to give a precipitate. The precipitate was collected by filtration, washed with water and dried to give 1.5 g of the desired product which was recrystallized from isopropyl alcohol/acetonitrile, as a white solid, mp 287°-290° C.

Provenance & Evidence