Methyl Isocyanate → HCID 15622814, compound

Participants

Reaction Steps

700 mg (3.31 mmol) of (2-oxopyrrolidin-1-yl)acetylpiperazine was dissolved in 10.5 ml of CH2Cl2, and 0.215 ml (3.64 mmol) of methyl isocyanate was added to the mixture under ice-cooling, and the mixture was warmed to room temperature and stirred for 1 hr. After evaporating CH2Cl2, the precipitated crystals were washed with Et2O and collected by filtration. By recrystallizing from EtOH-Et2O, 856 mg of the objective compound (yield: 96.3%) was obtained as colorless prisms.

Provenance & Evidence