Sulfuric Acid → HCID 14623682, compound

HRID 1199965Notes

Reaction equation

HRID 1199965 reaction equation
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:11]=[CH:12][C:13](=[O:16])[NH:14][N:15]=2)=[CH:6][CH:5]=1)[CH2:2][CH3:3].S(=O)(=O)(O)[OH:18]>C(OC(=O)C)(=O)C.[O-2].[O-2].[O-2].[Cr+6]>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:11]=[CH:12][C:13](=[O:16])[NH:14][N:15]=2)=[CH:8][CH:9]=1)(=[O:18])[CH2:2][CH3:3]

Participants

5

Reactant 2

HCID 1118Sulfuric AcidHCID 14623681HCID 14623681, compound

Product 1

HCID 14623682HCID 14623682, compound

Reagents, catalysts & solvents 2

HCID 10219390chromium (VI) trioxideCatalystHCID 7918Acetic AnhydrideSolvent2×

Procedure

A solution of chromium trioxide (6.5 g) in acetic anhydride (29 ml) was added dropwise to a stirred, cooled solution of 6-(4-n-propylphenyl)pyridazin-3(2H)-one (5.11 g) in acetic anhydride (25 ml) containing concentrated sulphuric acid (5 ml). The reaction mixture was stirred at room temperature for 16 hours and then poured into crushed ice (250 ml) to afford 6-(4-propionylphenyl)pyridazin-3(2H)-one (0.78 g), m.p. 202°-205° C.

Workup

  1. additionpoured

Sources & evidence

ORD record
ord-6cab5f953c864ac9b55e09cb25aa1dd4
Source dataset
uspto-grants-1990_02
Patent number
US04904664

Reaction notes

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