Acetone → HCID 14623684, compound

Participants

Reaction Conditions

Reaction Steps

In a similar manner to Example 3b) a mixture of 6-(4-propionylphenyl)pyridazin-3(2H)-one (2.28 g), formaldehyde (37% solution, 1 ml) and dimethylammonium chloride (1.25 g) in acetic anhydride (8 ml) was stirred at 90° C. for 11/2 hours. The cooled solution was poured into dry acetone (150 ml) and was evaporated to dryness under reduced pressure to afford a yellow oil. Trituration with dry acetone afforded 6-[4-(3-dimethylamino-2-methylpropionyl)phenyl]pyridazin-3(2H)-one hydrochloride (2.12 g), as a white solid.

Provenance & Evidence