HCID 19864507, compound → HCID 19864505, compound

Participants

Reaction Steps

3 g (8.1 mmol) of N-[{2-(4-chlorophenyl)-6-methylimidazo[1,2-a]pyridin-3-yl}methyl]-N,3-dimethylbutanamide hydrochloride is dissolved in 200 ml of acetic acid, 0.7 g of rhodium on alumina (5% rhodium) is added and the mixture is hydrogenated under a pressure of approximately 0.35 MPa (50 PSI) until absorption is complete. The catalyst is removed by filtration and the solvent evaporated off under reduced pressure. The residue is taken up with dichloromethane and the solution washed with bicarbonate water. The organic phase is separated after settling and dried over magnesium sulphate. After filtration and evaporation of the solvent, a solid residue is taken up with ether and purified by chromatography on a silica column. The hydrochloride is prepared therefrom in 0.1N hydrogen chloride in isopropyl alcohol. 1.55 g of the expected product is obtained.

Provenance & Evidence