Sodium Hydroxide → HCID 19864500, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 12.56 g (0.05 mole) of 3-acetamido-7-chloro-4-mercapto-quinoline and 120 g of polyphosphoric acid is heated to 140°-160° C. The reaction mixture is stirred at this temperature for 2 hours, cooled to 90° C., whereupon 700 ml of water are added under vigorous stirring. When the reaction mixture has cooled to 20° C., it is made alkaline by adding a sodium hydroxide solution. The resulting mixture comprising a precipitate is extracted three times with 150 ml of chloroform each. The chloroform layers are united and evaporated to 60 ml, whereupon 300 ml of ethanol are added. 9.3 g of 7-chloro-2-methyl-thiazolo[4,5-c]quinoline are obtained in the form of needle crystals. Yield 80%, m.p.: 181°-183° C.

Provenance & Evidence