HCID 70357434, compound → HCID 19864527, compound

Participants

Reaction Steps

4-(2-Benzyloxyphenyl)-2,6-dimethyl-3-[4-(3,5-dimethyl-1,2,4-triazol-4yl)butoxycarbonyl]-5-(N-pyrid-2-ylcarbamoyl)-1,4-dihydropyridine (0.3 g--see Example 11) was dissolved in ethanol (10 ml) containing 10% palladium-on-charcoal and the mixture was hydrogenated at room temperature under pressure (30 p.s.i.=206.8 kPa) for 4 hours. The catalyst was filtered off and the filtrate evaporated under vacuum. The residue was then chromatographed on silica gel eluting with EtOAc containing 15% Et2NH and the fractions containing the product were combined and evaporated to give the title compound, (0.12 g, 47%), m.p. 125°-135°.

Provenance & Evidence