反应详情

To a stirred solution of 2-methyl-1-(4-hydroxybutyl)imidazo[4,5-c]pyridine (0.5 g) in acetone (10 ml) at room temperature was added, dropwise, freshly distilled diketene (0.2 g). The solution was stirred at room temperature for 2 hours and then evaporated to dryness. The residue was chromatographed on silica gel eluting with a methylene chloride-ethyl acetate mixture and the fractions containing the product were evaporated under vacuum to leave the title compound, (0.51 g).

1. customevaporated to dryness
2. customThe residue was chromatographed on silica gel eluting with a methylene chloride-ethyl acetate mixture
3. additionthe fractions containing the product
4. customwere evaporated under vacuum