Ammonia → HCID 70357192, compound

HRID 1199988Notes

Reaction equation

HRID 1199988 reaction equation
O=[C:2]([CH3:21])[CH2:3][C:4]([O:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[C:19]2[CH:18]=[CH:17][N:16]=[CH:15][C:14]=2[N:13]=[C:12]1[CH3:20])=[O:5].[NH3:22]>C(O)C>[NH2:22][C:2]([CH3:21])=[CH:3][C:4]([O:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[C:19]2[CH:18]=[CH:17][N:16]=[CH:15][C:14]=2[N:13]=[C:12]1[CH3:20])=[O:5]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 19864538HCID 19864538, compound

Product 1

HCID 70357192HCID 70357192, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-(2-Methylimidazo[4,5-c]pyrid-1-yl)butyl 3-oxobutanoate (1.52 g) (see Preparation 6) was dissolved in ethanol (50 ml) containing dry silica gel (2.5 g) and gaseous ammonia was then bubbled through the mixture for 20 minutes. The mixture was stirred at room temperature for a further 11/2 hours and then filtered and evaporated to dryness leaving the crude title compound (1.54 g) which was used directly.

Workup

  1. customwas then bubbled through the mixture for 20 minutes
  2. filtrationfiltered
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-3e6647fa7e4b4c9a8695c736c26935c1
Source dataset
uspto-grants-1990_02
Patent number
US04904671

Reaction notes

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