反应详情

1-(4-Acetoxybutyl)-2-methylimidazo[4,5-c]pyridine (0.55 g) was dissolved in ethanol (10 ml) and 2M potassium hydroxide (2 ml) was added dropwise. The mixture was stirred at room temperature for 3 hours and then evaporated under vacuum. The residue was dissolved in 2M hydrochloric acid, washed with methylene chloride (2×20 ml), basified with solid NaHCO3 to pH 7.5 and then extracted with methylene chloride (10×20 ml). The combined organic extracts were evaporated under vacuum to leave the desired product as a brown oil (0.5 g).

1. customevaporated under vacuum
2. dissolutionThe residue was dissolved in 2M hydrochloric acid
3. washwashed with methylene chloride (2×20 ml)
4. extractionextracted with methylene chloride (10×20 ml)
5. customThe combined organic extracts were evaporated under vacuum