HCID 19864523, compound → HCID 19864518, compound

Participants

Reaction Steps

4-[4-(2-Hydroxyethyl)phenylamino]-3-nitropyridine (5.18 g) and stannous chloride dihydrate (22.56 g) were suspended in ethanol (100 ml) and heated at reflux for 45 minutes. The mixture was concentrated under vacuum, basified to pH8 with 2M sodium hydroxide solution and then extracted with ethyl acetate (3×200 ml). The combined organic extracts were dried over Na2SO4, filtered and evaporated under vacuum to give the crude product, (4.5 g), which was used directly in the next step.

Provenance & Evidence