反应详情

A solution of 1.42 g (5 mmol) of 6-(1,1-dimethylethyl)-3-hydroxy-2-phenyl-7-azabenzo[b]thiophene and 1.42 g sodium acetate in 20 mL of acetic anhydride was heated at reflux for 1 hour. The solution was concentrated and the residue was partitioned between ether and water. The ether layer was washed with sodium bicarbonate solution and brine, dried and concentrated. The residue was crystallized from ether-hexane to afford 1.49 g (91%) of fine white needles, m.p. 128°-9° C.

1. temperatureat reflux for 1 hour
2. concentrationThe solution was concentrated
3. customthe residue was partitioned between ether and water
4. washThe ether layer was washed with sodium bicarbonate solution and brine
5. customdried
6. concentrationconcentrated
7. customThe residue was crystallized from ether-hexane