Sulfuric Acid → HCID 178443067, compound

HRID 1200042Notes

Reaction equation

HRID 1200042 reaction equation
[C:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10]2[NH:14][N:13]=[N:12][N:11]=2)=[N:8][CH:9]=1)([OH:3])=[O:2].S(=O)(=O)(O)O.[CH2:20](O)[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35]>C1(C)C=CC=CC=1>[NH:14]1[C:10]([C:7]2[CH:6]=[CH:5][C:4]([C:1]([O:3][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH3:20])=[O:2])=[CH:9][N:8]=2)=[N:11][N:12]=[N:13]1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 2682Cetyl AlcoholHCID 178524274HCID 178524274, compound

Product 1

HCID 178443067HCID 178443067, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 1.65 g (8.6 mmol) of 5-carboxy-2-(5-tetrazolyl)-pyridine , 0.1 ml of concentrated sulfuric acid and 3.64 g (15 mmol) of 1-hexadecanol in 50 ml of toluene is refluxed for 48 h. The hot solution is filtered in order to eliminate the non-reacted starting material. The filtrate on cooling yields crystals of the title compound, m.p. 139°-140°.

Workup

  1. temperatureis refluxed for 48 h
  2. filtrationThe hot solution is filtered in order
  3. temperatureThe filtrate on cooling

Sources & evidence

ORD record
ord-00e3c7578d0d49c4949f3a1d124fb839
Source dataset
uspto-grants-1990_02
Patent number
US04904675

Reaction notes

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