2,5-Pyridinedicarboxylic acid → HCID 53877452, compound

Participants

Reaction Steps

2,5-Dicarboxy-pyridine (1.67 g, 0.01 mol) is suspended in 40 ml of dichloromethane. 2.8 ml of triethylamine are added dropwise, followed by 4.02 g (0.02 mol) of ethyl 2-bromo-2-ethoxy-acetate. The solution is stirred at room temperature for 2 h. After this period, the dichloromethane solution is filtered, washed with water, dried over magnesium sulfate and evaporated to dryness. The residue is purified by silica gel column chromatography (dichloromethane/ethyl acetate) to yield the title compound as a resin; IR (NaCl film): 1730 (CO), 1765 (CO) cm-1.

Provenance & Evidence