HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuryl chloride → Methyl 2-chloro-3-oxo-2,3-dihydrothiophene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | 3-Hydroxy-thiophene-2-carboxylic acid methyl ester | HCID 581127 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | Methyl 2-chloro-3-oxo-2,3-dihydrothiophene-2-carboxylate | HCID 15588102 | — |
Reaction Steps
Sulphuryl chloride (0.11 mol) was added to a stirred solution of methyl 3-hydroxythiophene-2-carboxylate (0.1 mol) (C. Corral, J. Lissavetzty; Syntheses (1984), 847) in anhydrous chloroform (50 ml). After stirring at room temperature for 4 hours the solvent was removed under reduced pressure and the residue used crude in the following preparations (m.p. 70°-71° C., hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04904686 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-c016b875267347e2bb1edf2a3d93ad84 |
| Source note | uspto-grants-1990_02 |