HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl 5-chloro-3-hydroxythiophene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 2-chloro-3-oxo-2,3-dihydrothiophene-2-carboxylate | HCID 15588102 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Methyl 5-chloro-3-hydroxythiophene-2-carboxylate | HCID 54706804 | — |
Reaction Steps
A solution of 2-chloro-2-methoxycarbonylthiophene-3(2H)-one (30 mmol) in acetic acid (20 ml) was saturated with dry hydrogen chloride gas. After standing for 3 days the solvent was removed under reduced pressure and the oily residue distilled to give a yellow liquid which crystallised on addition of aqueous acetic acid (m.p. 42°-44° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04904686 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-54ac88c49b634371b5a37340dd9d777a |
| Source note | uspto-grants-1990_02 |