反应详情

To a stirred suspension of 2-chloro-2-methoxycarbonylthiophen-3(2H)-one (6.35 g, 33 mmol) in acetic acid (20 ml) was added sulphuric acid (1.8 ml) in acetic acid (20 ml). The mixture was stirred until dissolved then methyl mercaptan was bubbled through for 0.5 hours (total approximately 2 g). The mixture was stirred at room temperature for 18 hours, poured onto ice-water and the oily precipitate extracted into dichloromethane. After evaporation of solvent the crude oil was used in the following preparation.

1. dissolutionuntil dissolved
2. custommethyl mercaptan was bubbled through for 0.5 hours (total approximately 2 g)
3. stirringThe mixture was stirred at room temperature for 18 hours
4. additionpoured onto ice-water
5. extractionthe oily precipitate extracted into dichloromethane
6. customAfter evaporation of solvent the crude oil
7. customwas used in the following preparation