HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → Methyl 3-hydroxy-5-(methylsulfonyl)thiophene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium methanesulfinate | HCID 2733271 | — |
| Reactant | Methyl 2-chloro-3-oxo-2,3-dihydrothiophene-2-carboxylate | HCID 15588102 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Methyl 3-hydroxy-5-(methylsulfonyl)thiophene-2-carboxylate | HCID 54724750 | — |
Reaction Steps
Sodium methane sulphinate (16 mmol) was added to a solution of 2-chloro-2-methoxycarbonylthiophene-3(2H)-one in acetic acid (20 ml) containing sulphuric acid (1.3 ml). After standing for 24 hours the precipitate was filtered, m.p. 138°-140° C. (acetic acid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04904686 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-64a1bc2a7e7e446ba20b025056d824ef |
| Source note | uspto-grants-1990_02 |