HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazole → methyl 3-hydroxy-5-(1H-pyrazol-1-yl)thiophene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazole | HCID 1048 | — |
| Reactant | Methyl 2-chloro-3-oxo-2,3-dihydrothiophene-2-carboxylate | HCID 15588102 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | methyl 3-hydroxy-5-(1H-pyrazol-1-yl)thiophene-2-carboxylate | HCID 54695607 | — |
Reaction Steps
Pyrazole (18 mmol) was added to a solution of 2-chloro-2-methoxycarbonylthiophene-3(2H)-one in acetic acid (10 ml). The mixture was allowed to stand at room temperature for 2 days and the precipitate filtered, m.p. 162°-164° C. (acetic acid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04904686 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-e138e10b4d0a478ba32d36d9460f4d52 |
| Source note | uspto-grants-1990_02 |