Hydrochloric Acid → Methyl 4,5-dichloro-3-hydroxythiophene-2-carboxylate

Participants

Reaction Steps

Dry hydrogen chloride gas was bubbled into a solution of crude 2,4-dichloro-2-methoxycarbonylthiophen-3(2H)-one (6.8 g, 30 mmol) in acetic acid (30 ml) until saturated. The mixture was allowed to stand for 2 days, concentrated under reduced pressure and the precipitate filtered and recrystallised from methanol, m.p. 107°-108° C.

Provenance & Evidence