Magnesium chloride hexahydrate → HCID 19864665, compound

Participants

Reaction Steps

5H-Dibenz[b,g]oxocin-6(7H)-one (3 g - as prepared in B) was dissolved in a mixture of formic acid (3 ml) and methylformamide (12 ml) containing magnesium chloride hexahydrate (0.6 g), and the solution was refluxed for three hours. The cooled reaction mixture was diluted with water and neutralised with sodium carbonate solution, then the product was extracted into 1,1'-oxybisethane. The extract was washed with water, sodium carbonate solution and water then dried over sodium sulphate, and evaporated to give 6,7-Dihydro-N-methyl-5H-dibenz[b,g]oxocine-6-formamide.

Provenance & Evidence