Sodium Hydroxide → HCID 15067926, compound

HRID 1200132Notes

Reaction equation

HRID 1200132 reaction equation
[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=[C:5]([C:13]([O:15]C)=[O:14])[C:4]=1[C:17]1[C:22]([C:23]([O:25]C)=[O:24])=[CH:21][C:20]2[O:27][CH2:28][O:29][C:19]=2[C:18]=1[O:30][CH3:31].[OH-].[Na+]>CO>[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=[C:5]([C:13]([OH:15])=[O:14])[C:4]=1[C:17]1[C:22]([C:23]([OH:25])=[O:24])=[CH:21][C:20]2[O:27][CH2:28][O:29][C:19]=2[C:18]=1[O:30][CH3:31]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14372323HCID 14372323, compound

Product 1

HCID 15067926HCID 15067926, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 20 ml of methanol was dissolved 1.75 g of dimethyl 2,2',3,4-tetramethoxy-3',4'-methylenedioxy-1,1'- biphenyl-6,6'-dicarboxylate obtained in Example 2, and 1 ml of a 10% aqueous solution of sodium hydroxide was added to the solution and the mixture was heated and refluxed for 16 hours. After termination of the reaction, the reaction mixture was cooled and the precipitated crystals were recovered by filtration and recrystallized from methanol to obtain 1.3 g of 2,2',3,4-tetramethoxy-3',4'-methylenedioxy-1,1' -biphenyl-6,6'-dicarboxylic acid (the yield was 81%).

Workup

  1. additionwas added to the solution
  2. temperaturethe mixture was heated
  3. temperaturerefluxed for 16 hours
  4. customAfter termination of the reaction
  5. temperaturethe reaction mixture was cooled
  6. filtrationthe precipitated crystals were recovered by filtration
  7. customrecrystallized from methanol

Sources & evidence

ORD record
ord-b81ed2b221444f14a2eee4be584729de
Source dataset
uspto-grants-1990_02
Patent number
US04904694

Reaction notes

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