Triphenylphosphine → HCID 14696294, compound

Participants

Reaction Steps

11.0 g of powdery N-(t-butoxycarbonyl)-O-benzyl-L-serine were added to 200 ml of a methylene chloride solution containing 5.0 g of α,α-dimethylbenzylamine and 10.0 g of triphenylphosphine. 20 ml of a methylene chloride solution containing 8.2 g of 2,2'-dipyridyl disulfide were then added dropwise. The mixture was then stirred for 1 hour at room temperature, after which the solvent was distilled off under reduced pressure and the residue was subjected to silica gel column chromatography. The title compound was obtained as an oil from the fraction eluted with a 2:1 by volume mixture of ethyl acetate and hexane. Yield 9.2 g.

Provenance & Evidence