Sodium Chloride → 4-((1R)-1-Aminoethyl)phenol

277 ml of a cooled 20% w/v aqueous solution of sodium hydroxide were added dropwise to 75.2 g (0.277 mole) of (R)-α-methyl-p-hydroxybenzylamine L-malate [obtained as described in step (c) above], and then the mixture was stirred at a temperature between 2° and 5° C. for 15 hours. At the end of this time, 60 g of sodium chloride were added, and the whole mixture was stirred at a temperature between 2° and 5° C. for a further 15 minutes. The crystals which precipitated were collected by filtration, and washed in turn with 100 ml of cold water and 100 ml of acetone to give 32.3 g (85.2%) of the title compound in the form of a colorless powder melting at 124°-125° C.

1. stirringthe whole mixture was stirred at a temperature between 2° and 5° C. for a further 15 minutes
2. customThe crystals which precipitated
3. filtrationwere collected by filtration
4. washwashed in turn with 100 ml of cold water and 100 ml of acetone

ORD record

ord-d3f52d8d0b7147e0839f95618a12eb40

Source dataset

uspto-grants-1990_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04904680