反应详情

[2-(1-Cyclohexenyl)-4-oxo-4H-[1]-benzopyran-8-yl]acetic acid (2.84 g), 2,2-dimethyl-1,3-dioxolan-4-methanol (3.96 g) and dicyclohexylcarbodiimide (2.28 g) were added to dichloromethane (30 ml) with ice cooling and then the mixture was stirred at room temperature for 18 hours. The mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography to obtain the title compound (2.65 g), yield 67%, m.p. 104°-105° C. (recrystallized from ethyl acetate).

1. concentrationThe mixture was concentrated under reduced pressure
2. customthe residue was purified by silica gel column chromatography
3. customto obtain
4. customthe title compound (2.65 g), yield 67%, m.p. 104°-105° C. (recrystallized from ethyl acetate)