HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-methyl-2-pyrrolidone → Cefadroxil hemihydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | N-Methylformamide | HCID 31254 | — |
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | Cefadroxil | HCID 47965 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Isopropanol methanol | HCID 21255859 | — |
| Product | Cefadroxil hemihydrate | HCID 67173987 | — |
Reaction Steps
Consequently the present invention relates to a method for producing crystalline cefadroxil hemihydrate, according to which a cefadroxil solvate of dimethylacetamide, of N-methyl-2-pyrrolidone or of monomethylformamide is slurried with a mixture methanol:isopropyl alcohol 30:7: to 70:30 by volume containing from 5% to 12% of water, at a temperature in the range of about +45° C. to +55° C. and then isolating the so obtained crystalline cefadroxil hemihydrate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04904776 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-594a95aea4b2430c951b99811ced5131 |
| Source note | uspto-grants-1990_02 |