Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | HCID 14996561 | HCID 14996561 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Cefadroxil hemihydrate | HCID 67173987 | 86.6% |
Reaction Steps
Cefadroxil monomethylformamide solvate (30 g) was slurried in a mixture of methanol (100 ml), isopropyl alcohol (47 ml) and water (13 ml) at 50° C. After 90' at 50° C. the mixture was cooled to 10° C., filtered and washed with acetone to yield 22.9 g of crystalline cefadroxil hemihydrate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04904776 |
|---|
| Source dataset | uspto-grants-1990_02 |
|---|
| ORD ID | ord-f78a4610a5264522a0bfd9305839f41a |
|---|
| Source note | uspto-grants-1990_02 |
|---|
